PRX Derm Perfexion is a skin rejuvenation treatment that delivers chemical peel results without the visible peeling. It works beneath the surface of the skin instead of on top of it, which is why the flaking stage traditional peels are known for does not happen here.
As a no-peel chemical peel, it's built for patients who want the results of a peel without the recovery that usually comes with one.
For patients who want peel-level results without a week of hiding indoors, that distinction is the whole appeal.
PRX Derm Perfexion is a non-invasive, in-office skin biorevitalization treatment built on the PRX-T33 formulation (also marketed as CALM Glow). It combines 33% TCA, hydrogen peroxide, and kojic acid to boost collagen and improve firmness without needles, frosting, or peeling downtime.
A formula developed for young, sensitive, already-compromised skin turns out to be gentle enough for adult skin too, without the surface trauma a traditional peel causes.
The treatment addresses dull skin, uneven tone, fine lines, skin laxity, and pigmentation, the same concerns a stronger peel would target, minus the recovery time that keeps some patients from choosing one.
PRX Derm Perfexion combines three active ingredients, and the mechanism depends on how they interact with each other.
The result is a treatment that stimulates cellular renewal at the layer where collagen and elastin are produced, without removing the epidermis, the surface layer responsible for visible peeling in a traditional peel.
The trade-off is intensity per session. A traditional peel makes a bigger change in a single visit because it removes the outer skin layer outright. PRX Derm Perfexion produces a milder, cumulative change per session, built through a series, in exchange for skipping the peeling entirely.
PRX Derm Perfexion is generally suited to patients dealing with:
It's also an option for patients who want peel-level results but can't build recovery time into their schedule, since there is no social downtime to plan around.
Not every skin concern is a fit for PRX Derm Perfexion. Deeper structural concerns, like significant acne scarring, may respond better to a treatment that reaches the dermis more directly, such as microneedling.
PRX Derm Perfexion also isn't recommended during pregnancy or breastfeeding, or for patients with a known allergy to any of its active ingredients. A consultation determines which approach fits your skin and confirms these factors.
At Anne Therese Aesthetic Medicine, all skin treatments are performed by licensed medical professionals. Dr. Anne Therese Stubbs, MD, Founder and Medical Director, oversees all treatment protocols at the practice. Her 14 years in emergency medicine before founding the practice inform how the team screens patients and structures safety protocols across the practice.
A licensed medical professional cleanses the skin, works the solution in using a massage technique, and finishes with nourishing products.
Afterward, some patients notice mild redness or slight tightness that resolves within a few hours. No visible peeling follows, so there's no recovery time to schedule around.
In the days following treatment, the same general skincare habits that support any in-office treatment apply: daily SPF 30+ sun protection, a gentle cleanser, and holding off on active ingredients like retinoids or acids until your provider confirms your skin has settled.
Because PRX Derm Perfexion doesn't strip the epidermis, this window tends to be shorter and less restrictive than what follows a traditional peel.
Optimal results typically require a series of three to five treatments, spaced several weeks apart. Results can last several months, and periodic maintenance sessions help sustain the improvement over time.
Because each session produces a milder change than a single aggressive peel, the series builds toward the cumulative result over several appointments. Patients preparing for an event, managing early fine lines, or maintaining results between more intensive procedures tend to be good candidates.
Pricing depends on the number of sessions your skin needs and how PRX Derm Perfexion fits into your individualized treatment plan. Because it's typically used as a series rather than a single visit, the relevant number is the cost of the full protocol, not a single session in isolation.
During a consultation, your provider can walk you through what a full course involves and what it costs for your goals.
Anne Therese Aesthetic Medicine offers PRX Derm Perfexion, with locations in Lewis Center and Gahanna, Ohio, and Cape Coral and Bonita Springs, Florida. Dr. Anne Therese Stubbs, MD, Founder and Medical Director, oversees treatment protocols across the practice. Her 14 years in emergency medicine before founding the practice inform how the team screens patients and structures safety protocols.
During a consultation, licensed medical professionals review your skin condition, treatment history, and goals to determine whether PRX Derm Perfexion is the right fit and how it sequences with any other treatments in your individualized treatment plan.
This overview is educational and doesn't replace a one-on-one evaluation. Your candidacy, protocol, and expected results are determined by a licensed medical professional during a consultation.
To schedule a skin consultation, contact the location nearest you.
PRX Derm Perfexion is built on the same formulation known as PRX-T33 (also marketed as CALM Glow): a combination of TCA, hydrogen peroxide, and kojic acid designed to stimulate the dermis without peeling the surface.
It addresses dull skin, uneven tone, fine lines, skin laxity, and pigmentation. Your provider will confirm which of these concerns apply to your skin and how PRX Derm Perfexion fits alongside any other treatments you're considering.
No visible peeling is the expected outcome. Some patients notice mild redness or tightness for a few hours after treatment, but the surface flaking associated with traditional peels does not occur here, since the treatment works beneath the epidermis rather than removing it.
PRX Derm Perfexion, microneedling, and laser treatments like Clear + Brilliant all stimulate collagen, but through different mechanisms: PRX Derm Perfexion uses a controlled acid formulation, microneedling uses mechanical micro-injury, and Clear + Brilliant uses fractional laser energy. Your provider can sequence more than one of these into a single treatment plan depending on your skin's concerns.
Some patients notice brighter, tighter-feeling skin after a single session, but the full effect builds across the recommended three-to-five-session series. A consultation sets expectations specific to your skin's starting point and goals.
Because there's no visible peeling to mark progress the way a traditional peel does, changes with PRX Derm Perfexion tend to show up as brighter, tighter-feeling skin rather than a dramatic single-session transformation. Early sessions in the series may show subtle improvement in tone and texture, with tightness and radiance building more noticeably as patients move through the full three-to-five-session protocol. Your provider can set expectations for what your specific starting point and goals should look like session to session.
